tag:blogger.com,1999:blog-19092890.post948464334306333360..comments2024-03-28T15:26:27.432+02:00Comments on Image Sensors World: Progress in pH Imager-Based Genome Sequencing Vladimir Koifmanhttp://www.blogger.com/profile/01800020176563544699noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-19092890.post-29174628038169266432012-12-07T22:40:41.505+02:002012-12-07T22:40:41.505+02:00Surface can be made hydrophilic to facilitate the ...Surface can be made hydrophilic to facilitate the wetting.<br /><br />And the wells' aspect ratio isn't and can't be that severe. The wells just have to be deep enough to hold the emPCR beads, and during synthesis nucleotides needs to easily diffuse in and H+ ions need to diffuse out. Shouldn't think of these as "pipes", "divots" would be closer. Thus a bit of surface hydrophilicity will suck the water above in quite easily.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19092890.post-14849373859275234832012-12-06T15:08:28.135+02:002012-12-06T15:08:28.135+02:00I do not know if it's easy, but Ion Torrent...I do not know if it's easy, but Ion Torrent's products prove that it's possible.Vladimir Koifmanhttps://www.blogger.com/profile/01800020176563544699noreply@blogger.comtag:blogger.com,1999:blog-19092890.post-15003435364538021682012-12-06T14:23:55.914+02:002012-12-06T14:23:55.914+02:00Thanks Vladimir ! But is it easy to fill the 1.6um...Thanks Vladimir ! But is it easy to fill the 1.6um micro pipe on the top of the pixel ? <br /><br />-yang niAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-19092890.post-32443693791094531852012-12-06T13:22:22.275+02:002012-12-06T13:22:22.275+02:00Why? To make more pH pixels on the same die, thus ...Why? To make more pH pixels on the same die, thus make genome analyzing process much faster and cheaper. They intend to hit the price target of $1000 per full genome, which is quite impressive, if achieved.Vladimir Koifmanhttps://www.blogger.com/profile/01800020176563544699noreply@blogger.comtag:blogger.com,1999:blog-19092890.post-70952024034677138192012-12-06T13:00:36.092+02:002012-12-06T13:00:36.092+02:00Why we need so small pixel pitch for pH sensing pl...Why we need so small pixel pitch for pH sensing please ? <br /><br />-yang niAnonymousnoreply@blogger.com