Yahoo: Anitoa, a Menlo Park, CA startup, demonstrates its low cost and portable chemiluminescence reader and applied it successfully with chemiluminescence immunoassay (CLIA). This CMOS-based solution is capable of detecting as low as a few ng/ML of analyte, such as protein macromolecules, in a sample. Applications of this technology ranges from clinical diagnostics to food safety and environmental monitoring.
A key component of Anitoa's portable chemiluminescence reader is its proprietary ULS24 CMOS bio-optical sensor chip with extreme low-light sensitivity. The ULS24 CMOS sensor also eliminates the need for a multi-sites scanning mechanism commonly used by most chemiluminescence readers. At a 5mmX5mm footprint and consumes only 30mW of power, Anitoa's ULS24 is especially well suited for point-of-care diagnostics applications.
Released in September 2014, Anitoa's ULS24 ultra-low light CMOS bio-optical sensor is said to be the first and only commercially available CMOS sensor that has the needed sensitivity to substitute the bulky and expensive photon multiplier tubes (PMT) and cooled-CCDs in a wide range of medical and scientific instruments. The ultra-low light sensitivity (3e-6 lux) of Anitoa's CMOS sensor is crucial for achieving good SNR in imaging molecular interactions based on fluorescent or chemiluminescence signaling principles.
"We are very pleased to see the test results coming back from our lab and our partners' labs showing the effectiveness of CMOS bio-optical sensors in chemiluminescence imaging. This not only validates the CMOS bio-optical sensor's ultra-low-light sensitivity, but also opens up the possibility for a new generation of low cost and portable molecular testing platforms", said Anitoa CEO Zhimin Ding.