Mentor Graphics publishes a whitepaper on using its FastSpice transient noise analysis for image sensor simulations. Some of the Mentor's claims are disputable, but probably nobody expects a deep understaning of CIS issues from an EDA company:
"Another type of temporal noise source is random telegraph signal (RTS) noise, which introduces “blinking pixels” from which the output exhibits three discrete levels. However, RTS noise does not appear to be a limiting factor on the performance of today’s image sensors."
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